A positive elevated rheumatoid factor (RF) can indicate the presence of an autoimmune disease such as rheumatoid arthritis (RA) or Sjögren’s syndrome. However, a negative antinuclear antibody (ANA) test does not rule out RA. The ANA test is sensitive but not specific to RA and can be positive in many healthy individuals or Show Full Answer

A positive elevated rheumatoid factor (RF) can indicate the presence of an autoimmune disease such as rheumatoid arthritis (RA) or Sjögren’s syndrome. However, a negative antinuclear antibody (ANA) test does not rule out RA. The ANA test is sensitive but not specific to RA and can be positive in many healthy individuals or those with other autoimmune conditions.

Key points:
- Positive RF: Suggests autoimmune disease, possibly RA.
- Negative ANA: Does not rule out RA.
- Further Testing: Anti-CCP antibody test is more specific for RA.

For a more accurate diagnosis, additional tests and clinical evaluations are necessary.

 This AI-generated response comes from myRAteam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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