The context provided does not contain specific information comparing the effectiveness of methotrexate combined with leflunomide versus methotrexate combined with hydroxychloroquine.

However, it does mention that
- Methotrexate combined with leflunomide has been shown to be safe and efficacious for the treatment of Show Full Answer

The context provided does not contain specific information comparing the effectiveness of methotrexate combined with leflunomide versus methotrexate combined with hydroxychloroquine.

However, it does mention that:
- Methotrexate combined with leflunomide has been shown to be safe and efficacious for the treatment of rheumatoid arthritis, providing statistically significant improvements in clinical outcomes.
- Methotrexate is often used in combination with hydroxychloroquine as part of triple therapy, but specific comparative effectiveness data between these combinations is not provided in the context.

For a detailed comparison, please consult a healthcare professional or refer to specific clinical studies.

 This AI-generated response comes from myRAteam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

The Combination of Leflunomide (Arava) and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis • Johns Hopkins Arthritis Center

Effectiveness of Combination Therapy vs. Monotherapy with Etanercept or Infliximab in Real-World Clinical Practice • Johns Hopkins Arthritis Center