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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Hi Everyone, I Have Just Put On Rheumalef (leflunomide) The Side Effects Looks Scary. I Am Not Sure If I Should Even Take It. Any Advice?

A myRAteam Member asked a question 💭
Phalaborwa, ZA

I still am on all the other medications like methotrexate, prednisone, salazopyrin (might be a different name in the US), coxleon and other immuno suppressants. My Dr. Did not discuss the side effects of the liver, kidneys, increased chances of cancer, dental issues, high risk of other infections, the list goes on. Is this really worth it?

August 14, 2024
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A myRAteam Member

I was put on this medication a couple of months ago, and they will monitor your blood work for any complications, but so far so good on my end. All RA meds have side effects whether they are biologics or not. It is a question of quality of life and slowing progression and protecting your other organs. I have had scleritis which is RA attacking your eyes, and it can affect your heart and lungs if it is left to just ravage your body. I don't think there is a completely safe med. And many times, just because it is listed as a side effect, doesn't mean everyone has these symptoms or issues.

August 14, 2024
A myRAteam Member

Leflunomide (Rheumalef) can indeed have side effects. Here are some common and serious side effects to be aware of:

Common Side Effects
- Diarrhea
- Vomiting
- Heartburn
- Headache
- Dizziness
- Weight loss
- Back pain
- Muscle pain or weakness
- Pain, burning, numbness, or tingling in the hands or feet
- Hair loss
- Leg Show Full Answer

Leflunomide (Rheumalef) can indeed have side effects. Here are some common and serious side effects to be aware of:

Common Side Effects:
- Diarrhea
- Vomiting
- Heartburn
- Headache
- Dizziness
- Weight loss
- Back pain
- Muscle pain or weakness
- Pain, burning, numbness, or tingling in the hands or feet
- Hair loss
- Leg cramps
- Dry skin

Serious Side Effects:
- Rash with or without a fever
- Hives
- Blisters or peeling of skin
- Mouth sores
- Itching
- Difficulty breathing
- New or worsening cough
- Chest pain
- Pale skin
- Nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark-colored urine, or flu-like symptoms

Important Notes:
- Leflunomide may increase the risk of certain types of cancer, although this has not been reported in clinical studies to date.
- Always follow your doctor's directions and discuss any concerns or side effects with them.
- Do not stop taking leflunomide without consulting your doctor.

It's crucial to have a conversation with your healthcare provider about your concerns and the risks versus benefits of taking this medication.

August 14, 2024
A myRAteam Member

Happy birthday Lanie. Hope you have a wonderful day

August 14, 2024
A myRAteam Member

I was on it but because of Neuropathy was taken off. I have exhausted on all the meds at that level rely now on the embrel injection weekly. Try it and see how you go

August 14, 2024
A myRAteam Member

Good morning Lanie ☀️ I took leflunomide for a few months. Didn’t agree with me. The worst side effect was terrible diarrhea. I went back on mtx. Now my liver numbers are high 🤪 so my dr cut the mtx dose in half. We’ll see what the blood work shows in 60 days. Hope today is kind to you 🤗

August 14, 2024

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