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Who Here Has Seronegative RA And How Do You Know For Sure It’s RA?

A myRAteam Member asked a question 💭
Williams, OR

I was originally diagnosed at 49 years old with a condition called poly myalgia rheumatica, which started as severe pain in my shoulders and hips (so bad I needed help getting up from a sitting position and getting dressed), but after a couple of months of high doses of prednisone (25mg daily) I was referred to a rheumatologist who diagnosed me with seronegative RA. I had a moderately high CRP and ESR. RA factor and ANA were negative. I do have an aunt who has seropositive RA. He put me on MTX… read more

June 1, 2024
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A myRAteam Member

I have a seronegative RA, I was diagnosed through MRI and ANA levels were elevated, other than that most of the blood work and xray was fine, I doubted it at first , to be honest it's hard to accept the diagnoses, but generally if you have pain and stiffness that is worst when you wake up or rest and anti inflammatory medication did not help , if the pain is symmetrical or semi symmetrical on both joints most likely its RA. That's from my experience

June 6, 2024
A myRAteam Member

Seronegative RA is diagnosed through a combination of methods since it doesn't produce the specific antibodies (anti-CCP and RF) that seropositive RA does. Here's how it's typically diagnosed:

1. Medical History and Physical Examination
- Questions about symptom onset, affected joints, pain description, fatigue, Show Full Answer

Seronegative RA is diagnosed through a combination of methods since it doesn't produce the specific antibodies (anti-CCP and RF) that seropositive RA does. Here's how it's typically diagnosed:

1. Medical History and Physical Examination:
- Questions about symptom onset, affected joints, pain description, fatigue, morning stiffness, and other symptoms.
- Evaluation of joints for signs of inflammation, joint strength, range of motion, and endurance.

2. Laboratory Tests:
- Blood tests for erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to check for inflammation.

3. Imaging Tests:
- X-rays to assess joint damage.

These methods help doctors differentiate seronegative RA from other conditions like osteoarthritis or psoriatic arthritis.

June 1, 2024

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