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Changing From Humira To Enbrel. Is There Anything That I Should Be Aware Of? Any Difference Between The Two? Thanks!

A myRAteam Member asked a question 💭
Rocky Point, NY

I am being treated of RA, OA, Lupus (in remission) and Fibromyalgia.

April 4, 2024
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A myRAteam Member

Switching from Humira (adalimumab) to Enbrel (etanercept) involves a few considerations:

1. **Mechanism of Action**: Both are TNF inhibitors used in rheumatoid arthritis treatment, but they work slightly differently at the molecular level. This difference might impact how well the treatment works for you or the side Show Full Answer

Switching from Humira (adalimumab) to Enbrel (etanercept) involves a few considerations:

1. **Mechanism of Action**: Both are TNF inhibitors used in rheumatoid arthritis treatment, but they work slightly differently at the molecular level. This difference might impact how well the treatment works for you or the side effects you experience.

2. **Administration**: Both medications are available in forms that allow for self-injection. Humira introduced the Humira Pen, and Enbrel has the Enbrel SureClick autoinjector. Both are designed to make the injection process simpler and less intimidating.

3. **Frequency of Dosing**: The dosing schedules for Humira and Enbrel differ. It's important to follow the specific dosing schedule prescribed by your healthcare provider for Enbrel, as it may not be the same as it was for Humira.

4. **Efficacy and Side Effects**: While both drugs are used to treat rheumatoid arthritis and have been shown to be effective, individual responses can vary. Some patients may find one drug works better for them or has fewer side effects.

5. **Biosimilars**: There are biosimilar versions available for both Humira and Enbrel. A biosimilar is a biologic medical product highly similar to another already approved biological medicine. Biosimilars offer more treatment options and may be more cost-effective.

6. **Cost and Insurance Coverage**: The cost and insurance coverage for these medications can vary. It's a good idea to check with your insurance provider regarding coverage for Enbrel, as switching medications might affect your out-of-pocket costs.

Always consult with your healthcare provider before making any changes to your treatment plan. They can provide personalized advice based on your medical history and current health condition.

April 4, 2024

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