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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has Anyone Had Itchiness, Especially At Night On Arms, From Hydrochloroquine (plaquenil)?

A myRAteam Member asked a question 💭
Orange, CT

I think I'm having a side effect after being on it for a year. Hoping to wean off it ASAP, but weaning off prednisone, so I'm afraid inflammation and other symptoms will return.

December 30, 2023
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A myRAteam Member

If you're experiencing itchiness on your arms at night from taking hydroxychloroquine (Plaquenil), it's important to contact your doctor. Itchiness can be a side effect of the medication, and your doctor can help determine if you're allergic to it or if you should stop taking it. They can also suggest an alternative Show Full Answer

If you're experiencing itchiness on your arms at night from taking hydroxychloroquine (Plaquenil), it's important to contact your doctor. Itchiness can be a side effect of the medication, and your doctor can help determine if you're allergic to it or if you should stop taking it. They can also suggest an alternative treatment if necessary. Remember, it's crucial to consult with your healthcare provider about any side effects you're experiencing.

December 30, 2023
A myRAteam Member

Hi Elyse,
I don't take hydroxy (I tried it briefly a few years ago but suffered an adverse reaction to it). I do, however, get itchy arms and was told it was due to my diabetes - go figure. You are so right when you wrote that it's so frustrating not knowing what causes what (I sometimes think that we're more often the medical professionals here!!). I hope you get some helpful answers. 🤗🤔

January 1, 2024
A myRAteam Member

I was thrilled with the results on hydroxychloroquine, aka Plaquenil, then I developed a full body rash. Both my rheumy and dermatologist said it was a reaction to the medication.

December 31, 2023
A myRAteam Member

Not diagnosed with fibromyalgia. I do have overlapping autoimmune diseases, so who knows. Rheumatologist says treatment is the same…I read itchiness is a possible side effect of Plaquenil. So hard to determine cause. I told rheumatologist last week. Thanks for your response.😊

December 31, 2023
A myRAteam Member

I am not on hydroxycloroquine but my arms are often itchy in the evening. Not sure why.

December 30, 2023

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