I did not do well with methotrexate. The side effects were challenging- extreme fatigue, no energy, depression, weight gain. I no longer use this med.

Yes its the exact same way for me

4 tabs Saturday and Sunday. Haven't noticed any problems.

Hello, When I first started on methotrexate, I felt horrible the day after. I did not make any plans for that day so I could be a couch potato. It did eventually get better, but I really dreaded taking it at first. My doctor had me split it up on the day I take it. I take 5 in the afternoon and the other five before I go to bed. It seemed to have helped. Good luck to you! Tammie :)

I took this for a very short period, it made me so sick. I was so tired, I didn't have any energy to just get out of bed. Wherever I took the shot, would swell up. This medication, was really bad for me.