My brother has been on methotrexate from the onset of his RA, so 6 years now. No issues except the weight loss/loss of appetite. My dad's been on methotrexate for over 10 years. Same results as my brother. When I got the seronegative RA our family line has I went with methotrexate and figured that would be it. Sadly, liver issues, so I was switched to Humira. I loved the methotrexate. No side effects except weight loss. I was chunky and happy to shed the 25 lbs. Humira worked for about a year, but now it's not as effective. I have more flares and limping and toes/feet problems. I'm talking to my rheumatologist in April about trying something else. Back taking Prednisone, eat like a hog, chunky again. Thanks to everyone for sharing their experiences with different medications, especially combinations. We're all different, so food, exercise type, supplements, and medications are all one big experiment.

I’ve been off and on for years. Now 6 pills once a week with no side effects.

Well I smoke, wait I did smoke and yes and from what Ive learned Methotrexate does play a part in it. I’ve been on it for over 12 years pill form then self injections in my stomach. I went to a neurologist and found out

I do. I don't think that related to Meths. Please have it checked. It sounds serious