There really isn't a best medicine. We all react differently to RA meds. Enbrel is the best for me.

I’m taking planquenil and RINVOQ now. I’ve tried Enbrel, Xeljanz, methotrexate, Humira, diclofenac in less than a two year period due to having fibromyalgia that made injectables impossible to take. I find the Planquenil a very underrated drug. It, combined with the RINVOQ, works well, especially for severe RA.

There isn’t one! 50% of the drugs work on 50% of the people for 50% of the time because we’re all different according to my rheumatologist. Find one that works for you!
All the best in your search! 💗💗

Unfortunately, it doesn’t seem to matter what the best RA meds are, on the market. It depends on how YOUR body reacts to the meds you are prescribed. Everyone will react differently. Just because one person has success with certain meds, doesn't mean that it will absolutely do the same for you.
Finding the right meds is super frustrating and takes time.

I don't get side effects anymore. When I first took it, I got headaches mainly. It went away after about 3-6 months.