You should feel relief within a day or so. Mine typically lasts for about 6-8 weeks depending on the area

I seem to have longer-lasting relief from my cortisone shots than most. I have had them in my back for degenerative disc disease, spondylosis, and spinal stenosis and it takes a few days to get the relief that is minimal at best. I can get them in my thumb and relief is almost immediate. Also, I get them in my right shoulder for excruciating pain. It starts to work in a day or so and lasts for 3 or more months. My shoulder and the right thumb are where I realize that I am lucky when reading some of your responses. I also take Orencia. That took about 3 months to notice any results. But I think it helps my shoulder a lot.

What are you taking for your RA itself. Are you on any course of treatment?

PattiHendreson I was on the max.dose of Methotextrate,I had to go to the injection because I was being nauseated often.You want believe the difference in the injection.I will take it any day over the tablets.

You need to alternate heat and ice to help with pain at the injection site. Some people will experience a roid flare, but it should ease with the ice and heat alternations. Also, tylenol or ibuprofen helps too.