@A myRAteam Member i have been taking leflunomide for about 7 months with no side effects. The headaches are pretty bad at first but after about a few weeks they stop completely! I love it! I also take it right before bed

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A myRAtea...

Try taking it as an injection. They are small needles, so not a huge deal. No gastro issues that way I found. I switched several years ago.

I developed Methotrexate toxicity that caused.me to develop life threatening bacterial infection in lungs. ICU stay and near intubation was quite a scare and led to eventual septicemia. Was in and out of hospital and rehab facilities and spent 1 day home in 14 weeks. This happened in 2012 and started my struggle with this terrible disease RA.

I couldn’t handle oral methotrexate. Lots of stomach issues. My Dr put me on injections. Even then I had to do smaller doses twice a week until I got used to it. Now I can tolerate a full dose

I started with oral methotrexate and had stomach pain,and diarrhea and severe nausea. I would take the methotrexate on Thursday and by Friday afternoon I would start with the stomach problems. They didn't believe it was the medicine either. So I finally told them I wouldn't take it anymore. So after being off the oral for a few weeks they started me on the injectable. I have not had any side effects of the injectable. But now they feel I need something added. So this week I added Remicade infusions to the methotrexate. We'll have to see what happens. So far so good.