I take 1 mg folic acid pill, prescription. Also, I sometimes get mouth sores from either the MTX ot the Sjogrens disease. My dentist recommended taking iron tablets, OTC. It took about 3 days and my mouth sores began disappearing.

Pat

It seemed to take a looooong time, but my rheumatologist is very conservative and increased it VERY gradually. I mean like 4 months or so!! Hang in there. I got worse before the tide turned and I started to feel better.

It is different on each person, it may take a month.

I mentioned the mouth sores because the MTX can cause them. That way you have an avenue to try to get rid of them.

Pat

Hi Sunflowerspa3, It's Pat. I started off taking 6 Methotrexate pills once a week. I now take 8 each week. Initially, I took an anti-inflammatory twice daily in addition to the MTX, and they helped. I am allergic to Meloxicam and the Diclofenac caused stomach troubles. I am now on only Methotrexate and folic acid for this. Still have success...

Pat