I am seronegative also. I started having pains in my hands and feet in 2003 or 2004. My hands would turn a peachy color, and holding a piece of paper between my fingers hurt. My doctor started me on mobic. I took other nsaids. She had told me i was a puzzle because all my test were pretty much negative. First hand xrays according to radiologist showed some early signs of rhematoid disease. I had read some books on RA and one said talked about seronegative RA, which i thought i had. Then i read another book that said there was no such thing. Then my first RA doctor retired, and i got a new doctor. She is the one who told me i had RA and she had run the vectra test. Then i started taking hydroxycloriquine, tramadol, then arava, and now i started xljanz 3 weeks ago. In one book i read it reccomended that even seronegative patients be treated aggressively, to get it undercontrol early and to lesson joint damage.

I'm also seronegative. But no MRI's. Just exrays. I'm on a biologic and it has helped when not much else has. But I also have osteoarthritis. I am rarely without a symptom. Fatigue seems to be my #1 symptom that does not respond to any medicine. It took my doctor over a year to find a medicine that worked for me.

I have been Sero negative RA for 23years I also have oesteoarthritis. I have always been treated aggressively by my Consultant, Plaquenil, sulphasalazine, Methotrexate, Methotrexate and Enbrel then Metho and Roactemra now just Roactemra occ predisolone when flair ups my inflammatory markers are normal at present.
I believe because I was treated the rate of my decline and the damage to my joints has been minimalised although I am now noticing more damage, although much less than some other people I know who haven't been treated as aggressive ly.

@A myRAteam Member Vectra test is a blood test where the lab takes 12 protiens from your blood and measure them for inflamation, and gives it a number grade.

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A myRAtea...

I am seronegative and took pictures of my hands and knees. Both were red and swollen. But it helped when I went yesterday. My levels elevated during flair in November.