At the beginning of taking them I was feeling sick 24/7 and lost loads of weight until my bloods came out bad which was due to an upset liver. I had to stop taking all medication until the bloods came back clear. During that break I started eating again. I had to start on half the dose and increase it every other week.... and it happened again. After restarting again I actually never increased the dose; I stayed in a dose of 7.5 mg a week and had to come clean with the rheumy at the next appointment. Got a sigh, but my bloods were better, so he agreed I could stay on the lower dose (which I'm still on). Feel sick still quite often, but now know to have a good meal before taking it, so it's not that bad. As long as it helps me not having to go through that agonizing pain again.

My side effects are manageable. I take 6 pills on Friday night, with food, then go to bed. I feel a little queasy and don't sleep well that night. Then on Saturday, I feel as if I have a massive hangover. Headache, no energy, still queasy and all I want to do is lie on the sofa. Today the rheumatologist prescribed composine, which may help with the nausea. The mtx seems to be helping some, so at this point it is 'worth' losing Saturday to have less RA pain. Good luck, I hope your meds help!

The day I take it (Thursday, today lol ) I rake it around 430-5 and I can literally predict that in about 5-6hrs around 1030-11 the nausea hits. Hot/cold. And I knock out (fall asleep) within an hour of the nausea hitting. I used to have my hands puff up and be in a lot of pain after I took it. I still get achey but it's not as bad as when I first started. I have a sensitive stomach so that doesn't help nausea. I also got super bad migraines when I first started. I haven't lost ANY weight, I have gained 5 to 10 lbs since December. I am on 6, 2.5 tablets. 2mg prednisone 1mg folic acid. I think that's it lol

If you take the pills you should have something to eat before taking them or they can upset your stomach make you feel a little bit nauseous. If you get the injection you should always stick it in the fatty tissue around your stomach instead of your leg Unless you have a very sensitive stomach then just put it in the fatty area on your leg. I was on the free year and I never had any side effects from it whatsoever I think you always have more side effects when you take the pill then the injection. Never leave your doctor's office without asking these questions about me being nauseous should I take the pills vs. Injection and if I take the injection what's the best place to inject it my stomach area on my leg. Sometimes your doctor has really good ideas and sound Advice right away you should stick the injection.

All these side effects are scary, I've have noticed now the day after I take them I'm really sluggish and feel like poop. Maybe I never really paid attention? Wow I never got any of these other than really fatigued. I'm sorry for all you guys having bad experience with Mtx